GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2243480 | 1 | rs56016656 | chr7:65383481 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.95 | 9.06E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs56016656 | chr7:65383481 | RABGEF1 | chr7:66093890-66276446:+ | 0.53 | 6.46 | 2.51E-10 | Diabetic kidney disease |
| THCA | cis | rs4959799 | 1 | rs56026460 | chr6:3291264 | PSMG4 | chr6:3259162-3268300:+ | -0.33 | -5.54 | 5.09E-8 | Survival in rectal cancer |
| THCA | cis | rs8170 | 1 | rs56028644 | chr19:17388790 | ABHD8 | chr19:17402941-17414282:- | 0.25 | 4.1 | 4.94E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs56028644 | chr19:17388790 | ANKLE1 | chr19:17392454-17398454:+ | 0.29 | 4.96 | 1.0E-6 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs56028644 | chr19:17388790 | OCEL1 | chr19:17337055-17340027:+ | 0.21 | 4.2 | 3.21E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs9475752 | 1 | rs56030203 | chr6:56783857 | BEND6 | chr6:56819773-56892138:+ | -0.31 | -6.73 | 4.73E-11 | Menarche (age at onset) |
| THCA | cis | rs9475752 | 1 | rs56030203 | chr6:56783857 | KIAA1586 | chr6:56911384-56920021:+ | -0.34 | -5.49 | 6.68E-8 | Menarche (age at onset) |
| THCA | cis | rs8049439 | 1 | rs56040780 | chr16:28861881 | EIF3C | chr16:28722782-28747052:+;chr16 | 0.3 | 5.41 | 9.72E-8 | Educational attainment;Inflammatory bowel disease (early onset);Educational attainment (years of education) |
| THCA | cis | rs8049439 | 1 | rs56040780 | chr16:28861881 | EIF3CL | chr16:28699879-28747052:+;chr16 | 0.52 | 10.48 | 2.77E-23 | Educational attainment;Inflammatory bowel disease (early onset);Educational attainment (years of education) |
| THCA | cis | rs8049439 | 1 | rs56040780 | chr16:28861881 | SULT1A1 | chr16:28616918-28634866:- | -0.17 | -4.05 | 5.87E-5 | Educational attainment;Inflammatory bowel disease (early onset);Educational attainment (years of education) |
| THCA | cis | rs8049439 | 1 | rs56040780 | chr16:28861881 | TUFM | chr16:28853732-28857729:- | 0.31 | 11.07 | 1.62E-25 | Educational attainment;Inflammatory bowel disease (early onset);Educational attainment (years of education) |
| THCA | cis | rs6978712 | 1 | rs56040865 | chr7:127152442 | GRM8 | chr7:126078652-126893147:- | -0.35 | -3.57 | 0.000394 | Medication adherence in chronic diseases |
| THCA | cis | rs12188164 | 1 | rs56042615 | chr5:437667 | C5orf55 | chr5:441645-443258:- | 0.33 | 8.44 | 3.87E-16 | Cystic fibrosis severity |
| THCA | cis | rs17761864 | 1 | rs56043407 | chr17:2166078 | SRR | chr17:2207248-2228553:+ | -0.84 | -17.62 | 6.87E-54 | Esophageal cancer (squamous cell) |